Nottingham Forest and Aston Villa reach the Europa League semi-finals, while Braga and Freiburg also advance in a dramatic night of European action.
Manchester United loosened Arsenal's grip on the Premier League title race with a 3-2 win in north London on Sunday.
Manchester City defeated Brentford 3-0, closing the gap on Premier League leaders Arsenal. Liverpool drew with Chelsea, while other key Premier League results impacted European qualification hopes.
Manchester City and Arsenal face off in a crucial Premier League clash, with the title race hanging in the balance as City look to seize momentum.
Arsenal maintained control of the Premier League title race as they chiselled out a nervy 2-1 win over London rivals Chelsea to open up a five-point lead at the top of the table on Sunday.
First-half goals by Jakub Kiwior and Leandro Trossard looked like being enough for a lacklustre Arsenal against a lively Palace side who equalised with an Eberechi Eze volley.
IMAGES from the English Premier League matches played on Saturday
Images from the English Premier League matches played on Saturday
LATE MILEY GOAL SENDS NEWCASTLE THROUGH
Manchester United defeated Aston Villa to strengthen their position in the Premier League top four, while Liverpool were held to a draw by Tottenham Hotspur.
Manchester City halved Arsenal's lead at the top of the Premier League to three points with a 3-0 win over visitors Fulham, while Aston Villa stayed in the frame with a late 1-0 victory at home to Brighton & Hove Albion on Wednesday.
Promoted Sunderland, who have defied expectations to stay in the top half of the Premier League table, could be the worst affected with six players going to the tournament, while the likes of Fulham, Manchester United, Burnley and Crystal Palace will also have to make do without some key personnel.
Arsenal's Premier League title prospects were enhanced without them even kicking a ball on Wednesday as their closest challengers Manchester City and Aston Villa both dropped points.
Arsenal seized control of the Premier League title race as Bukayo Saka's goal secured a priceless 1-0 win at Brighton and Hove Albion and Manchester City could only draw 2-2 at home to relegation-threatened Nottingham Forest.
Manchester City manager Pep Guardiola admitted he was surprised that Norwegian striker Erling Haaland declined to take a penalty for his side in Saturday's FA Cup final against Crystal Palace with the kick subsequently being missed by Omar Marmoush.
Selhurst Park continues to prove a bafflingly tough place to play for United, who have not won there in their past five games and have just one goal to show for that stretch.
Cash on target as Villa hand Man City their first defeat since August
Second-string Liverpool were thumped 3-0 by Crystal Palace as Ismaila Sarr struck twice for the visitors in the League Cup on Wednesday, booking the London side's spot in the quarter-finals and piling more misery on Arne Slot's struggling side.
Manchester City defeated Salford City in the FA Cup, while Burnley suffered a surprising defeat to Mansfield Town. West Ham United and Norwich City also secured victories in their respective matches.
IMAGES from the Premier League matches played on Sunday
A round-up of Saturday's action in the Premier League.
Manchester City posted a hard-fought 1-0 victory over Brentford to jump to fifth spot in the English Premier League table on Sunday.
Manchester City maintained their squeeze on Arsenal at the top of the Premier League with a 3-0 victory at Crystal Palace on Sunday, a result that keeps Pep Guardiola's side lurking two points behind the leaders and ready to pounce.
From Royal Challengers Bengaluru's historic first IPL title to star javelin thrower Neeraj Chopra finally breaking the iconic 90-meter mark to India women winning their first cricket World Cup, this was the year of long-awaited victories and record-breaking feats.
Goals from Omar Marmoush and Antoine Semenyo powered Manchester City to a muchneeded 20 home win over Wolverhampton Wanderers on Saturday, lifting Pep Guardiola's men provisionally to within four points of leaders Arsenal in the Premier League title race.
Arsenal missed a chance to tighten their grip on the Premier League title race with a 1-1 draw at 10-man Chelsea on Sunday.
City, Liverpool all cruise in respective FA Cup matches played on Saturday.
Liverpool secured a dominant win over West Ham, while other Premier League matches saw Brentford edge Burnley in a seven-goal thriller and Everton secure a late victory against Newcastle.
Arsenal's Max Dowman impressed manager Mikel Arteta as he became the club's youngest starter at just 15 years and 302 days in Wednesday's 2-0 League Cup win over Brighton & Hove Albion, earning the coach's praise for his impact in the game.
Gabriel Martinelli scored his first hat-trick for Arsenal as the Premier League leaders beat second-tier strugglers Portsmouth 4-1 to reach the FA Cup fourth round.
IMAGES from the EPL matches played on Saturday
Arsenal's miserly defence has conceded three Premier League goals so far this season and manager Mikel Arteta hopes their fortress-like foundation can finally deliver the silverware that has eluded the North London club for so long.
Championship side Oxford United beat League Two's MK Dons on penalties after their match ended 1-1, while a couple of League One teams moved on, with Wigan Athletic beating Championship side Preston North End 1-0, and Port Vale defeating League Two's Fleetwood Town 1-0.
Carragher said manager Arne Slot should build the team around Alexander Isak and Florian Wirtz.
Arsenal maintained a searing pace at the top of the Premier League with a straightforward 2-0 win at Burnley, while Liverpool snapped a dreadful four-match losing run with a 2-0 victory over Aston Villa to climb provisionally to third.
Arsenal's Calafiori secures 1-0 win at Manchester United; Crystal Palace hold Chelsea to 0-0 draw.
Erling Haaland took his league tally this season to 11 in eight games with both goals in City's 2-0 home win over Everton -- a result that temporarily put City above Arsenal on goals scored.
Liverpool end victorious season with 1-1 draw with Crystal Palace
Chelsea battled from two goals down to beat West Ham 3-2 in the Premier League on Saturday with a stoppage-time Enzo Fernandez winner.